Oct 26, 2017

Dr. Cecily Quinn Shares her Thoughts on PathVision from Faxitron

Dr. Cecily Quinn

Dr. Cecily Quinn from the School of Medicine, University College Dublin shares her thoughts on PathVision from Faxitron......

PathVision has revolutionized breast specimen imaging. The large size of the cabinet is a major advance on previous models, making it possible to x-ray all types of surgical specimens. In particular, PathVision has greatly enhanced the pathology workup of surgical specimens from patients with ductal carcinoma in situ, multi-focal invasive carcinoma, and post-neoadjuvant chemotherapy.

In DCIS, individual slice x-rays permit precise localization of calcification and associated changes. This allows focused block taking to ensure comprehensive microscopic examination of the abnormal tissue, assisting the detection of accompanying invasive carcinoma that may alter treatment recommendations.

Easy visualization of multiple tumors facilitates correlation with radiological findings and helps to distinguish between a continuous process and true multifocality, with implications for cancer staging and personalized therapy.

PathVision is extremely valuable in the workup of post-neoadjuvant chemotherapy specimens particularly when the patient has had a good clinical and radiological response. Visualization of the marker clips placed by the radiologist at the time of initial diagnosis guides the pathologist to the 'tumor bed'. This can be difficult to discern with the naked eye. Detailed microscopic examination of 'tumor bed’ is essential to assess the degree of pathological response which is the gold standard in terms of evaluating the efficacy of treatment.

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